February 6, 2024
Testosterone is truly a life source for the male body. Produced primarily in the testes by specialized Leydig cells, testosterone travels through the body via the bloodstream and binds to receptors on target tissues. There are testosterone receptors all over the body.
Additionally, As one might expect, many receptors are present in the genital area, but the largest concentration exists in the heart and brain. It is the receptor sites in the brain that create sexual desire, which in turn triggers the release of nitric oxide to facilitate an erection.
Moreover, Luteinizing Hormone (LH), produced by the pituitary gland, stimulates Leydig cells in the testicles to produce testosterone. The pituitary is like a hormone thermostat. As it senses the body’s need for testosterone, it releases LH to stimulate the testicles to produce testosterone.
In addition, Testosterone starts to decline because of the aging of the Leydig cells in the testicles and a decline in the pituitary gland’s ability to produce LH. The result is andropause or hormonal aging. Decline starts at about age 27 or 28; its effects can usually be felt by age 35.
Fact: Testosterone is an "anabolic steroid," a term that engenders negative connotations with men who follow sports. Thus, the bodies of both men and women produce anabolic steroids (testosterone) naturally. Men require it to live. The negative connotation comes from athletes and bodybuilders abusing combinations of synthetic testosterone—a practice called "stacking."
Fact: Testosterone is both safe and healthy when used correctly. Studies are now suggesting that healthy levels of testosterone help prevent Alzheimer's.
Fact: When done correctly, there are no adverse side effects from testosterone therapy.
Fact: Replacing testosterone to healthy levels will fix the below symptoms in 3 to 6 weeks.
The good news is that testosterone replacement therapy can quickly and safely correct andropause symptoms and low testosterone (low T), but it does require continuation for the rest of your life. Additionally, some men have difficulty accepting this fact. The way to view this "rest of your life" thing is to consider that your grandfather had the same problem -- you have a choice he did not have -- you can fix it.
Though everyone is different, here is a general progression of how things will change after you start testosterone therapy:
As mentioned earlier, treatment of low T is safe when done correctly. It is important to note that testosterone replacement therapy does not increase but instead decreases the chances of developing prostate cancer.
In addition, One of the causes of prostate cancer is excess estrogen. Excess estrogen in men occurs as testosterone declines, allowing the male body to accumulate fat—primarily belly fat—which contains an enzyme called aromatase, which converts testosterone to estrogen.
Moreover, Estrogen may convert to a metabolite, 16 alpha hydroxyl estrone, and on to 4 alpha hydroxyl, a carcinogen that can cause prostate cancer. We control the level of estrogen as part of our treatment.
Increased estrogen adds to the symptoms of andropause and, as noted above, is unhealthy for the prostate and heart. Using a medication to suppress excess estrogen during testosterone therapy is critical. If good lifestyle habits are practiced, fat will disappear over 3 to 6 months, and conversion to estrogen will stop.
Again, testosterone does not cause prostate cancer. It is the conversion of testosterone to estrogen, as well as lifestyle and heredity, that causes an enlarged prostate and increases the risk of cancer. Increasing testosterone levels and controlling estrogen lowers the risk of prostate cancer.
Lab testing produces three numbers:
Total testosterone is the number most commonly used and quoted, and this also reflects a lack of knowledge of the person doing so. Moreover, The problem is that most testosterone in any human body is inactive and bound to protein molecules by SHBG. Only testosterone that is not bound to protein molecules, or free testosterone, is active in the system. Therefore, free testosterone is a key to treatment.
Testosterone levels start to decline at about age 26 or 27. Most men start to feel the effects of low T, as free T levels decline to below 140pg. We replace testosterone with levels men had when they were younger and felt their best—250 to 350pg of free T. The “normal” range for free T is 80pg to 350pg (note: range may vary depending on the lab doing the testing). Thus, Laboratory ranges are determined by testing both sick and healthy men. Sick (andropause) is at the lower end of the range. Healthy is the upper end of the range of 250 to 350pg.
Note: Don’t let your doctor tell you, “You have normal testosterone for your age.” Thus, If you test at the middle or lower end of the range, and more importantly, if you have symptoms, you must investigate treatment.
When testosterone is introduced from outside the body, the glands that produce testosterone read that the body has an adequate supply and, therefore, does not need to work as hard.
The result is that natural production can decline, and testicles can shrink. This can be avoided by having you take a medication to stimulate your testicles as you use testosterone.
Moreover, We use two stimulating medications—HCG injections or clomiphene tablets, which do not require an injection. Your option to stimulate and what medication you will use will be discussed with you.
There is no better way a man aged 35 or older can take action, spend a reasonable amount of money, and have a more significantly improved quality of life than to treat hormone deficiency. Thus, If you are having symptoms, the question is not, “Should I replace hormones?” The question should be, “Who do I work with to replace hormones with healthy levels?”
For more info about Andropause Treatment, Visit the Core Medical Group website now.
